Nobivac® L4 Questions and Answers
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What strains of leptospirosis does Nobivac L4 cover against?
- L. interrogans serogroup Canicola serovar Canicola to reduce infection and urinary excretion
- L. interrogans serogroup Icterohaemorrhagiae serovar Copenhageni to reduce infection and urinary excretion
- L. interrogans serogroup Australis serovar Bratislava to reduce infection
- L. kirschneri serogroup Grippotyphosa serovar Bananal/Liangguang to reduce infection and urinary excretion
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What is the interval for Nobivac L4?
Administer two vaccinations of 1 dose (1 ml) of vaccine with an interval of 4 weeks to dogs from 6 weeks of age onwards.
The first vaccination can be administered from 6 to 9* weeks of age and the second vaccination from 10 to 13 weeks of age.
*In cases of a high level of MDA, first vaccination is recommended at 9 weeks of age
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What is the duration of immunity for Nobivac L4?
Duration of immunity: 1 year.
Revaccination: Dogs should be re-vaccinated annually with one dose (1 ml) of vaccine
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What is the onset of immunity for Nobivac L4?
The onset of immunity following the 2nd vaccination of the primary course is 3 weeks.
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Can Nobivac L4 be given at the same time with other Nobivac vaccines?
Safety and efficacy data are available which demonstrate that this vaccine can be mixed and administered with vaccines of the Nobivac series containing canine distemper virus, canine adenovirus type 2, canine parvovirus (strain 154) and/or canine parainfluenza virus components for subcutaneous administration. The product information of the relevant Nobivac vaccines should be consulted before administration of the mixed product.
Safety and efficacy data are available which demonstrate that this vaccine can be administered on the same day but not mixed with vaccines of the Nobivac series containing Bordetella bronchiseptica and/or parainfluenza virus components for intranasal administration.
Safety data are available which demonstrate that this vaccine can be administered at the same time but not mixed with the inactivated vaccine of the Nobivac series against Bordetella bronchiseptica.
For simultaneous use, 1 dose of a Nobivac vaccine containing canine distemper virus, canine adenovirus type 2, canine parvovirus, and/or canine parainfluenza virus components should be reconstituted with 1 dose (1 ml) of Nobivac L4. The mixed vaccines should be at room temperature (15 °C – 25 °C) before they are administered by subcutaneous injection.
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Can Nobivac L4 be used in pregnancy?
Nobivac L4 can be used during pregnancy.
We do not hold specific data regarding use during lactation and therefore cannot recommend this use during this period.
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Are there any breed contraindications for Nobivac L4?
There are no breed specific contraindications for Nobivac L4.
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What are the storage requirements for Nobivac L4?
Nobivac L4 requires storage in a refrigerator between 2 oC and 8 oC. Do not freeze. Protect from light.
Product images are representations of packaging and may not accurately reflect the current packaging available in the GB marketplace.
Date of preparation: August 2025
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Nobivac® L4 contains inactivated Leptospira strains: L. interrogans serogroup Canicola serovar Portland-vere (strain Ca-12-000), L. interrogans serogroup Icterohaemorrhagiae serovar Copenhageni (strain Ic-02-001), L. interrogans serogroup Australis serovar Bratislava (strain As-05-073) and L. kirschneri serogroup Grippotyphosa serovar Dadas (strain Gr-01-005). POM-V.
Further information is available from the SPC, datasheet or package leaflet.
Advice should be sought from the medicine prescriber.
Prescription decisions are for the person issuing the prescription alone.
Use Medicines Responsibly.
MSD Animal Health UK Limited, Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK
Registered in England & Wales no. 946942