Nobivac^® Pi Questions and Answers

For active immunisation of dogs from the age of 8 weeks onwards to reduce clinical signs of canine parainfluenza infection and to reduce viral shedding.

Onset of immunity: 4 weeks after vaccination. See the section below on Pi intervals.

Duration of immunity: has not been demonstrated, but an anamnestic response is produced in dogs given a revaccination one year after basic vaccination.

Nobivac Pi has been shown to be safe for use in pregnant bitches that have been vaccinated before pregnancy with the Pi vaccine of the Nobivac series.

We do not hold specific data regarding use during lactation and therefore cannot recommend this use during this period.

Nobivac Pi requires storage in a refrigerator between 2 ^oC and 8 ^oC. Do not freeze. Protect from light. Care should be taken to avoid prolonged or repetitive exposure to high ambient temperatures following withdrawal from the refrigerator prior to use.

There are no breed specific contraindications for Nobivac Pi.

Safety and efficacy data (viral excretion) are available which demonstrate that this vaccine can be mixed and administered with the inactivated vaccines of the Nobivac series against canine leptospirosis caused by all or some of the following serovars: L. interrogans serogroup Canicola serovar Canicola, L. interrogans serogroup Icterohaemorrhagiae serovar Copenhageni, L. interrogans serogroup Australis serovar Bratislava, and L. kirschneri serogroup Grippotyphosa serovar Bananal/Liangguang.

The product information of the relevant Nobivac vaccines should be consulted before administration of the mixed product. When mixed with Nobivac leptospirosis vaccines at annual revaccination, it has been established that there is no interference with the anamnestic response induced by the injectable canine parainfluenza virus component.

After administration with one of the leptospirosis vaccines, a mild and transient increase in body temperature (≤ 1°C) may occur for a few days after vaccination, with some pups showing less activity and/or a reduced appetite. A small transient swelling (≤ 4 cm), which can occasionally be firm and painful on palpation, may be observed at the site of injection. Any such swelling will either have disappeared or be clearly diminished by 14 days post-vaccination.

After mixed administration of an overdose of Nobivac Pi and an overdose of the leptospirosis vaccines of the Nobivac series, transient local reactions such as diffuse to firm swellings from 1 to 5 cm in diameter may be observed, usually these will persist no longer than 5 weeks, however some may take a little longer to completely disappear.

Safety and efficacy data are available which demonstrate that this vaccine can be mixed and administered with the inactivated vaccine of the Nobivac series against rabies or the inactivated vaccine against rabies and leptospirosis, where applicable. After administration with the rabies containing vaccines transient local reactions such as diffuse to firm swellings from 1 to 4 cm in diameter may be observed for up to 3 weeks after vaccination. The swellings may be painful for up to 3 days post dosing.

Safety data are available which demonstrate that this vaccine can be administered at the same time but not mixed with the inactivated vaccine of the Nobivac series against Bordetella bronchiseptica. 

When this vaccine is administered in association with the inactivated vaccine of the Nobivac series against Bordetella bronchiseptica, the demonstrated antibody response data of this vaccine are the same as when this vaccine is administered alone.

When Nobivac Pi is used with any of the other Nobivac vaccines referred to above, the minimum vaccination age for each vaccine must be taken into account such that at the time of vaccination, the dogs are at or older than the oldest minimum vaccination age for the individual vaccines.

No information is available on the compatibility of this vaccine when used with any other veterinary medicinal product except the products mentioned above. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.

• Before the age of 12 weeks:

Two vaccinations, each with a single dose: the first vaccination from the age of 8 weeks onwards and the second vaccination 2 - 4 weeks later.

• From the age of 12 weeks onwards:

Single vaccination, with one dose per animal.

Every year with a single dose.

To reconstitute freeze dried small animal Nobivac vaccines which include instructions to be reconstituted with Nobivac Solvent.

Nobivac Solvent requires storage not exceeding 25 °C and protected from light. Do not freeze.

Shelf life of the veterinary medicinal product as packaged for sale: 2 years

* Nobivac FeLV is presented as a suspension for injection therefore does not require reconsitution.

Each vaccine is formulated on the basis of a minimum immunising dose, not a dose per body weight. Therefore the full vaccine dose/reconstituted amount is the minimal immunising dose.

In order for the product shelf-life to be as it is stated on the product's SPC it should be stored as per the datasheet's storage requirements. This will always be our recommendation for product use.

In the case of any doubt it would be advisable to contact the Technical Product Support team before discarding any product.

In the event where it is advisable to discard product it may be possible to claim on the practice's insurance. Our Technical Product Support team can write a letter of support for insurance claims, pertaining to deviations in storage conditions, should you require it.