Nobivac^® DHP Questions and Answers

Nobivac DHP is for the active immunisation of dogs:

• To reduce clinical signs of disease caused by canine distemper virus infection
• To prevent clinical signs and viral excretion caused by canine parvovirus infection
• To reduce clinical signs of canine contagious hepatitis and viral excretion due to canine adenovirus 1 infection
• To reduce clinical signs of respiratory infection and viral excretion caused by adenovirus type 2 infection

Where earlier protection is required a first dose may be given to puppies from 6 weeks of age, but because maternally derived passive antibody can interfere with the response to vaccination a final dose should be given 2–4 weeks later i.e. at 10 weeks of age or older. 

Nobivac DHP requires storage in a refrigerator between 2 ^oC and 8 ^oC. Do not freeze. Protect from light.

A single injection should establish active immunity in dogs of 10 weeks of age or older. 

The minimum duration of immunity has been established as 3 years.

The onset of immunity is 7 days after the second vaccination if given, or 7 days after a single dose of vaccine when administered to a dog over 10 weeks of age.

There are no breed-specific contraindications for Nobivac DHP.

Nobivac DHP can be used in pregnant bitches which have previously been vaccinated with the CDV (strain Onderstepoort), CAV2 (strain Manhattan LPV3) and CPV (strain 154) antigens included in the Nobivac vaccine series.

We do not hold specific data regarding use during lactation and therefore use must be on a risk vs. benefit decision during this delicate time for the bitch.

Safety and efficacy data (viral excretion) are available which demonstrate that this vaccine can be mixed and administered with the inactivated vaccines of the Nobivac series against canine leptospirosis caused by all or some of the following serovars: L. interrogans serogroup Canicola serovar Canicola, L. interrogans serogroup Icterohaemorrhagiae serovar Copenhageni, L. interrogans serogroup Australis serovar Bratislava, and L. kirschneri serogroup Grippotyphosa serovar Bananal/Liangguang.

The product information of the relevant Nobivac vaccines should be consulted before administration of the mixed product. 

Safety and efficacy data are available which demonstrate that this vaccine can be administered on the same day, but not mixed, with the live vaccine for intranasal administration of the Nobivac series against infectious tracheobronchitis caused by Bordetella bronchiseptica and/or canine parainfluenza virus. 

Safety and efficacy data are available which demonstrate that this vaccine can be administered at the same time but not mixed with the inactivated vaccine of the Nobivac series against Bordetella bronchiseptica.

After mixed administration of an overdose of Nobivac DHP and an overdose of the leptospirosis vaccines of the Nobivac series, transient local reactions such as diffuse to firm swellings from 1 to 5 cm in diameter may be observed, usually these will persist no longer than 5 weeks, however some may take a little longer to completely disappear.

When Nobivac DHP is used with any of the other Nobivac vaccines referred to above, the minimum vaccination age for each vaccine must be taken into account such that at the time of vaccination, the dogs are at or older than the oldest minimum vaccination age for the individual vaccines.

Safety and efficacy data are available which demonstrate that this vaccine can also be administered on the same day with Nobivac^® Solvent or Nobivac^® Rabies. These can be used to reconstitute the freeze-dried Nobivac DHP.