What is Innovax-ND-ILT?
Innovax ND-ILT is a dual-construct HVT vaccine that provides long-term protection against three of the most important infectious diseases that threaten commercial poultry operations; Newcastle disease virus (NDV), infectious laryngotracheitis virus (ILTV), and Marek’s disease virus (MDV).
What is a dual-construct HVT vaccine?
HVT (herpesvirus of turkey) is a vaccine virus that has been used to aid protection against Marek’s disease for decades. The DNA of this virus is used as a backbone, and fragments of the genetic material from ND virus and ILT virus are inserted at a site within the HVT DNA that does not have a significant impact on the function or replication of the HVT virus itself. These fragments of genetic material tell the birds’ cells to produce immunogenic proteins normally associated with an ILT or ND infection, stimulating cell-mediated immunity and antibody production against these infections1.
Does Innovax-ND-ILT contain live ND and ILT viruses?
No, the vaccine consists of live HVT viruses containing genes that code for proteins produced by ND and ILT. The ND and ILT vaccine viruses used in Innovax-ND-ILT do not spread horizontally and do not revert to virulence.1
What reactions were observed in Innovax-ND-ILT trials?
Innovax-ND-ILT has an excellent safety profile. No adverse reactions or MD lesions were observed in overdose trials following a 10-fold dose of vaccine administered by either in-ovo or subcutaneous injection. Trials also demonstrated no significant statistical difference on hatchability or weight gain vs controls.1
Can we use Innovax-ND-ILT vaccine with other HVT or rHVT based vaccines?
Concurrent vaccination with other HVT vaccines is contraindicated because there can be significant interference between other HVT or rHVT vaccines and Innovax-ND-ILT.
How quickly does immunity develop against MD, ND & ILT?
The onset of immunity for Innovax-ND-ILT following in-ovo or subcutaneous injection are as follows:
ND: 5 weeks of age
ILT: 4 weeks of age
MD: 9 days
What is the duration of immunity?
Protection against ND lasts for a duration of 62 weeks.
Protection against ILT lasts for a duration of 62 weeks.
Protection against MD lasts for a duration of the entire risk period.
What other vaccines are compatible with Innovax-ND-ILT
Innovax-ND-ILT can be mixed in the same solvent and administered by the subcutaneous route with Nobilis® Rismavac. For this mixed use, an onset of immunity of 5 days has been demonstrated for MD.
When early challenge with ND is a concern, day-old spray vaccination with Nobilis® ND Clone 30 vaccine can be used alongside injectable hatchery vaccination or in ovo injection of Innovax-ND-ILT. The live ND vaccine provides early protection, and Innovax-ND-ILT extends that protection for the life of the flock without further boosting in the field.
Nobilis® IB Ma5 or Nobilis® IB 4-91 can be administered to day-old chicks vaccinated either by the subcutaneous or in ovo route with Innovax-ND-ILT.
Not answered your question?
1. Gergen, L et al. 2019, Avian Pathology Vol 48, No. 1, pages 45 - 56. https://doi.org/10.1080/03079457.2018.1546376
Innovax®-ND-ILT contains cell-associated live recombinant turkey herpesvirus (strain HVT/NDV/ILT), expressing the fusion protein of Newcastle disease virus and the glycoproteins gD and gI of infectious laryngotracheitis virus: 103.3 – 104.3 PFU. POM-V.
Nobilis® Rismavac contains live cell associated Marek’s disease virus strain CVI988 ≥ 3.0 log10 TCID50. POM-VPS.
Nobilis® ND Clone 30 contains live Newcastle disease virus, strain Clone 30 ≥ 6.0 log10 ELD50. POM-VPS
Nobilis® IB Ma5 contains live Avian Infectious Bronchitis virus strain IB Ma5: ≥ 3.5 log10 EID50. POM-VPS
Nobilis® IB 4-91 contains live attenuated avian Infectious Bronchitis Virus (IBV) variant strain 4-91: ≥3.6 log10EID50. POM-V
Further information is available from the SPC, datasheet or package leaﬂet. MSD Animal Health UK Ltd. Registered ofﬁce Walton Manor, Walton, Milton Keynes MK7 7AJ, UK. Registered in England & Wales no. 946942. Advice should be sought from the medicine prescriber.
Use Medicines Responsibly.
UK-INX-210600003 Tech Bulletin - Introduction to Innovax-ND-ILT
UK-INX-210600004 Tech Bulletin - Innovax-ND-ILT 60 Weeks with Nobilis Rismavac
UK-INX-210600005 Innovax-ND-ILT PDF + Print Detailer