What does Nobivac DHPPi provide protection against?
For active immunisation of dogs:
- To prevent mortality and clinical signs caused by canine distemper virus infection.
- To reduce clinical signs of infectious hepatitis and viral excretion due to canine adenovirus type 1 infection.
- To prevent mortality, clinical signs and viral excretion following canine parvovirus infection.
- To reduce clinical signs and viral excretion caused by canine parainfluenza virus infection and to reduce clinical signs of respiratory disease and viral excretion following adenovirus type 2 infection.
What is the interval for Nobivac DHPPi for a puppy under 10 weeks of age?
Where earlier protection is required a first dose may be given to puppies from 6 weeks of age, but because maternally derived passive antibody can interfere with the response to vaccination a final dose at 10 weeks of age or older is generally recommended.
For an optimal response to the parainfluenza component, animals should be vaccinated twice, 2-4 weeks apart with the final vaccination at 10 weeks of age or older.
In the event that the initial primary course dose of Nobivac DHPPi is delayed to 10 weeks of age or older, a single dose of Nobivac Pi at 12 weeks of age or older should suffice to establish optimal immunity for this component.
What are the storage requirements for Nobivac DHPPi?
Nobivac DHPPI requires storage in a refrigerator between 2oC and 8oC. Do not freeze. Protect from light. Care should be taken to avoid prolonged or repetitive exposure to high ambient temperatures following withdrawal from the refrigerator prior to use - in hot summer conditions vaccine potency can be severely reduced within a few hours.
If the animal is over 10 weeks of age, what is the protocol for Nobivac DHPPi?
A single injection should establish active immunity to canine distemper, infectious canine hepatitis and disease caused by canine parvovirus infection in dogs of 10 weeks of age or older.
In the event that the initial primary course dose of Nobivac DHPPi is delayed to 10 weeks of age or older, a single dose of Nobivac Pi at 12 weeks of age or older should suffice to establish immunity for this component.
What is the duration of immunity for Nobivac DHPPi?
At least three years for the canine distemper virus, canine adenovirus and canine parvovirus vaccine components.
The duration of immunity for the canine parainfluenza virus component has not been demonstrated, but an anamnestic response is produced in dogs given a revaccination one year after basic vaccination. Annual revaccination with the canine parainfluenza virus vaccine component is recommended.
What is the onset of immunity for Nobivac DHPPi?
The onset of immunity is 1 week for canine distemper virus, canine adenovirus and canine parvovirus vaccine components and 4 weeks for canine parainfluenza virus vaccine component.
Are there any breed-specific contraindications for Nobivac DHPPi?
There are no breed-specific contraindications for Nobivac DHPPi.
Can Nobivac DHPPi be used during pregnancy?
Nobivac DHPPi can be used in pregnant bitches which have previously been vaccinated with the CDV (strain Onderstepoort), CAV2 (strain Manhattan LPV3), CPV (strain 154) and CPi (strain Cornell) antigens included in the Nobivac vaccine series.
We do not hold specific data regarding use during lactation and therefore use must be on a risk vs benefit decision during this delicate time for the bitch.
Can Nobivac DHPPi be given with other Nobivac vaccines?
Safety and efficacy data (viral excretion) are available which demonstrate that this vaccine can be mixed and administered with the inactivated vaccines of the Nobivac series against canine leptospirosis caused by all or some of the following serovars: L. interrogans serogroup Canicola serovar Canicola, L. interrogans serogroup Icterohaemorrhagiae serovar Copenhageni, L. interrogans serogroup Australis serovar Bratislava, and L. kirschneri serogroup Grippotyphosa serovar Bananal/Liangguang.
The product information of the relevant Nobivac vaccines should be consulted before administration of the mixed product. When mixed with Nobivac leptospirosis vaccines at annual revaccination, it has been established that there is no interference with the anamnestic response induced by the injectable canine parainfluenza virus component.
After mixed administration of an overdose of Nobivac DHPPi and an overdose of the leptospirosis vaccines of the Nobivac series, transient local reactions such as diffuse to firm swellings from 1 to 5 cm in diameter may be observed, usually these will persist no longer than 5 weeks, however some may take a little longer to completely disappear.
When Nobivac DHPPi is used with any of the other Nobivac vaccines referred to above, the minimum vaccination age for each vaccine must be taken into account such that at the time of vaccination, the dogs are at or older than the oldest minimum vaccination age for the individual vaccines.
Safety and efficacy data are available which demonstrate that this vaccine can also be administered on the same day with Nobivac Solvent or Nobivac Rabies. These can be used to reconstitute the freeze-dried Nobivac DHPPi.
Note that we do not recommend physical mixing of Nobivac DHPPi with both Nobivac leptospirosis and rabies vaccines in the same syringe- this 3 vaccine combination would constitute an off-label use for which there is not adequate data.
Note also that the use of Nobivac Lepto2 with or without Nobivac injectable canine freeze-dried vaccines is on-label with respect to concurrent vaccination with Nobivac Rabies (i.e. at a separate injection site). In respect of Nobivac L4 and Rabies vaccination, concurrent use or mixing of these two products remains off-label use at the current time.
Further information is available from the SPC, Datasheet or package leaflet.
Not answered your question?
Nobivac® DHPPi contains live canine distemper virus (strain Onderstepoort), canine adenovirus type 2 (strain Manhattan LPV3), canine parvovirus (strain 154) and canine parainfluenza virus (strain Cornell). POM-V.
Nobivac® Lepto 2 contains inactivated Leptospira interrogans serogroup canicola (strain Ca-12-000) and icterohaemorrhagiae (strain 820K). POM-V.
Nobvac® L4 contains inactivated Leptospira strains: L. interrogans serogroup Canicola serovar Portland-vere (strain Ca-12-000), L. interrogans serogroup Icterohaemorrhagiae serovar Copenhageni (strain Ic-02-001), L. interrogans serogroup Australis serovar Bratislava (strain As-05-073) and L. kirschneri serogroup Grippotyphosa serovar Dadas (strain Gr-01-005). POM-V.
Nobivac® Rabies contains inactivated Rabies virus (strain Pasteur). POM-V.
MSD Animal Health UK Limited. Registered office Walton Manor, Walton, Milton Keynes MK7 7AJ, UK. Registered in England & Wales no. 946942.
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