Porcine Reproductive and Respiratory Syndrome (PRRS)

Porcine Reproductive and Respiratory Syndrome (PRRS) is an infection caused by the PRRS virus (PRRSv) and often compromises the health and profitability of pig herds. It causes respiratory problems in growing and finishing pigs plus reproductive failure in breeding herds. 

The economic impact of PRRS in a finishing unit is substantial. In a breeding herd it is dramatic and generally lasts several months until the herd reaches a stable condition. However, reproductive problems may reoccur if the breeding herd is destabilised due to recycling of the PRRS virus from the finishing herd or excreting gilts. It is important to prevent the virus taking hold through good biosecurity, management practices and vaccination.

Signs of PRRS

The signs of PRRS vary depending on the age of the pig.

Neonatal piglets

PRRSv infection alone will not always show symptoms. Neonatal piglets can display a variety of clinical signs. The most characteristic are heavy breathing, rapid breathing and death.

Growers and finishing pigs

PRRSv infection alone will not always show symptoms. However, it plays a major role in developing Porcine Respiratory Disease Complex. Because PRRSv will weaken the immune system, weaned and finishing pigs will often pick up a secondary virus and/or bacteria and develop pig respiratory disease.

If clinical signs are present, they are usually respiratory and include:

• Fever
• Sneezing
• Hyperpnea
• Dyspnea
• Coughing
• Pneumonia
• Lethargy
• Periocular oedema
• Oculonasal discharge

Breeding herds

In breeding herds, PRRSv causes porcine respiratory and reproductive disease symptoms. 

Diagnosis of PRRS

Confirming PRRS is complicated as symptoms are not exclusive to the PRRSv. Confirming the virus is present requires:

• Serology (blood testing)
• Virus isolation testing
• Reverse Transcriptase Polymerase Chain Reaction (RT-PCR)
• Nucleotide or amino acid sequencing

Prevention of PRRS

The best approach is prevention through good biosecurity, management and vaccination. Gilts entering the breeding unit should be acclimatised. Strict adherence needs to be paid both to the all-in, all-out principle and to the unidirectional flow of animals during the nursery and growing phases.

Understanding the virus

The PRRS virus is a single-strand RNA virus.

• Order: Nidovirales
• Family: Arteriviridae
• Genus: Arterivirus.

The PRRSv is transmitted through close contact and body fluids. The virus enters and replicates in macrophages (white blood cells of the immune system). The resulting porcine respiratory and reproductive disease is dependent on the age of the pigs affected.

The PRRSv also interacts with other viruses to cause severe pig respiratory disease. The mechanism is still under investigation; however, it has been demonstrated that:

• Mycoplasma hyopneumoniae enhances the pathological effects of PRRSv
• PRRSV enhances the pathological effects of Swine Influenza
• PRRSV predisposes pigs to infection and disease caused by Streptococcus suis bacteria
• PRRSV can cause a loss of the bactericidal (bacteria fighting) function of pulmonary intravascular macrophages in the lungs

It is still not possible to conclude which are the most important combinations of pathogens or to define the importance of PRRSV in the severity of pig respiratory disease. This is difficult to prove experimentally due to pathogenicity of virus strains used, timing of infections, serological status of pigs used and the lack of predisposing or stress factors due to housing and/or management. Clinical experience in the field has shown that the occurrence of new respiratory pathogens result in increasingly complex respiratory problems and improved performance has been observed in herds vaccinated for PRRSV.

Porcilis® PRRS contains Live attenuated PRRS virus strain DV POM-V
Further information is available from the SPC, datasheet or package leaflet. 
Advice should be sought from the medicine prescriber. 
Prescription decisions are for the person issuing the prescription alone. 
Use Medicines Responsibly. 
 
MSD Animal Health UK Limited, Walton Manor, Walton, Milton Keynes, MK7 7AJ, UK 
Registered in England & Wales no. 946942