Bovilis^® INtranasal RSP™ Live Questions and Answers

For the active immunisation of calves from the day of birth onwards to reduce clinical signs of respiratory disease and viral shedding from infection with BRSV and PI3.

Onset of immunity:

BRSV: 6 days (for calves vaccinated from the day of birth onwards)

5 days (for calves vaccinated from the age of 1 week onwards)

PI3: 1 week

The duration of immunity is 12 weeks.

Nasal use. Calves can be vaccinated from the day of birth onwards.

Reconstitute lyophilisate with solvent as described below. Ensure that the lyophilisate is completely reconstituted before use. The reconstituted vaccine is an orange/brown to off-pink or pink coloured suspension.

Administer a single dose of 2 ml reconstituted vaccine per animal in one nostril.

Instructions for reconstitution:

1 and 5 dose presentations:

For proper reconstitution of the lyophilisate, transfer the solvent to the vial with the lyophilisate (2 ml for the 1 dose, 10 ml for the 5 dose; also see the table below) using a needle and syringe. The vacuum in the vaccine vial will allow quick emptying of the syringe. Then resuspend by shaking. The vaccine suspension can be drawn up in a syringe with a clean tip. The vaccine in the syringe is now ready for administration, directly from the tip of the syringe. A spraying device is not required.

10 and 20 dose presentations:

For proper reconstitution of the lyophilisate, transfer 10 ml of the solvent to the vial with the lyophilisate using a needle and syringe. The vacuum in the vaccine vial will allow quick emptying of the syringe. Then resuspend by shaking. Completely draw up the vaccine suspension and transfer it back to the solvent vial in order to get the correct dose/volume ratio for the respective presentation (20 ml for the 10 dose, 40 ml for the 20 dose; also see the table below). The vaccine suspension can be drawn up in a syringe with a clean tip. The vaccine in the syringe is now ready for administration, directly from the tip of the syringe. A spraying device is not required. When vaccinating animals, it is recommended to change syringes or tips of a multidose syringe between animals to avoid transmission of pathogens.

Bovilis INtranasal RSP Live Reconstitution and Application Instructions:

Lyophilisate: Store in a refrigerator (2°C – 8°C). Do not freeze. Protect from light.

Solvent: Store below 25°C if stored independently from the lyophilisate. Do not freeze.

The shelf life of Bovilis INtranasal RSP Live is 6 hours once reconstituted.

The withdrawal period following Bovilis INtranasal RSP Live is zero days.

Can be used during pregnancy.

The safety of the veterinary medicinal product has not been established during lactation.

Yes, Bovilis INtranasal RSP Live can be administered on the same day but not mixed with Bovilis Nasalgen^®-C. The vaccines should be given into different nostrils. The product information of that veterinary medicinal product should be consulted before administration.