What does Bravoxin provide protection against?
For the active immunisation of sheep and cattle against disease associated with infections caused by Clostridium perfringens type A, C. perfringens type B, C. perfringens type C, C. perfringens type D, Clostridium chauvoei, Clostridium novyi type B, Clostridium septicum, Clostridium sordellii and Clostridium haemolyticum and against tetanus caused by Clostridium tetani.
For the passive immunisation of lambs and calves against infections caused by the above mentioned clostridial species (except C. haemolyticum in sheep).
What is the onset of immunity for Bravoxin?
Two weeks after the basic vaccination course (as demonstrated by serology only).
What is the duration of active immunity for Bravoxin?
An anamnestic humoral immune response (immunological memory) to all components was demonstrated 12 months following the primary course of vaccination.
As demonstrated by serology only:
12 months against C. perfringens types A, B, C and D; C. novyi type B; C. sordellii and C. tetani.
< 6 months against C. septicum; C. haemolyticum and C. chauvoei.
12 months against C. tetani and C. perfringens type D.
< 12 months against C. perfringens types A, B and C.
< 6 months against C. novyi type B; C. septicum; C. sordellii; C. haemolyticum and C. chauvoei.
What is the duration of passive immunity for Bravoxin?
Duration of passive immunity
As demonstrated by serology only is:
At least 2 weeks for C. septicum and C. chauvoei.
At least 8 weeks for C. perfringens type B and C. perfringens type C, and at least 12 weeks for C. perfringens type A; C. perfringens type D; C. novyi type B; C. tetani and C. sordellii.
No passive immunity was observed for C. haemolyticum.
At least 2 weeks for C. sordellii and C. haemolyticum.
At least 8 weeks for C. septicum and C. chauvoei and at least 12 weeks for C. perfringens type A; C. perfringens type B; C. perfringens type C; C. perfringens type D; C. novyi type B and C. tetani.
What is the withdrawal period following the use of Bravoxin?
The withdrawal period following the use of Bravoxin is zero days.
What reactions to the vaccine may be seen?
Swelling at the injection site was observed very commonly in clinical studies. This may reach up to a mean value of 6 cm in sheep and 15 cm diameter in cattle; sometimes reactions of up to 25 cm diameter may be seen in cattle.
Most local reactions resolve within 3-6 weeks in sheep and in less than 10 weeks in cattle. In a minority of animals they may persist longer.
An abscess may develop commonly.
Skin discolouration at the injection site (which returns to normal as the local reaction resolves) may occur commonly.
Mild hyperthermia may occur commonly.
Localised pain at the injection site for 1-2 days post first vaccination may occur uncommonly.
Anaphylactic reactions were observed in very rare cases in spontaneous pharmacovigilance reports. In such cases appropriate treatment such as adrenaline should be administered without delay.
Can the second vaccination of the Bravoxin primary course act as the pre-lambing booster?
To provide passive protection of the offspring, via the colostrum, a single booster dose should be administered between 8 and 2 weeks before parturition, if animals have received a full primary vaccination course before pregnancy.
What are the storage requirements for Bravoxin?
Store and transport refrigerated (2 °C - 8 °C). Do not freeze and protect from light.
What is the shelf life of Bravoxin once broached?
The shelf life of Bravoxin once broached is 8 hours.
Further information is available from the SPC, Datasheet or package leaflet.
Date of preparation: February 2022
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Bravoxin® suspension for injection for cattle and sheep contains Clostridia vaccine antigens. POM-VPS
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