What does Bovilis IBR Marker Live provide protection against?
Active immunisation of cattle to reduce the intensity and duration of the clinical respiratory signs induced by an infection with BHV-1 and to reduce nasal excretion of field virus.
What is the onset of immunity following primary vaccination for Bovilis IBR Marker Live?
An increase in immunity was demonstrated 4 days after intranasal vaccination and 14 days after intramuscular vaccination of 3 month old seronegative animals.
What is the duration of immunity for Bovilis IBR Marker Live?
After intranasal administration to 2 week old calves immunity lasts at least until the age of 3-4 months. In the presence of maternally derived antibodies, the protection of the vaccine may not be complete until a second vaccination as per SPC.
This second vaccination should be administered at 3-4 months of age and will result in protective immunity that lasts for at least 6 months.
Single intranasal or intramuscular vaccination of 3 month old animals provides protective immunity (reduction of clinical signs and reduction of viral excretion), which was demonstrated via challenge 3 weeks after vaccination. Reduction of viral excretion is maintained for at least 6 months after single vaccination.
Revaccination to ensure protection after the initial 6 month protection period has elapsed will result in protective immunity that lasts for 12 months.
What is the minimum age that Bovilis IBR Marker Live can be used from?
Bovilis IBR Marker Live can be used at a minimum age of 2 weeks and up to 3 months if given intranasally. From the age of 3 months it can be given intranasally or intramuscularly
What is the vaccination protocol for Bovilis IBR Marker Live?
Dosage: a single dose of 2 ml reconstituted vaccine per animal.
Method of administration:
- From the age of 3 months onwards: intranasal use or intramuscular use.
- At an age between 2 weeks and 3 months: intranasal use.
For intranasal use (1 ml in each nostril), the use of a nozzle is recommended.
- Basic vaccination: Vaccinate each animal from 3 months of age onwards with one single dose.
- Early protection schedule: When the first vaccination is given between the age of 2 weeks and 3 months, a second vaccination should be given at an age of 3-4 months.
First revaccination: The first revaccination should be given 6 months after primary vaccination. Bovilis IBR marker Inac can alternatively be used for this revaccination.
Subsequent revaccinations: All following revaccinations should be given at an interval no greater than 12 months. Bovilis IBR marker Inac can alternatively be used for these revaccinations.
The product literature of Bovilis IBR marker Inac should be consulted before using it for revaccination.
What are the storage requirements for Bovilis IBR Marker Live?
Lyophilisate: Store in a refrigerator (2 °C to 8 °C). Do not freeze. Protect from light.
Solvent: Store below 25 °C if stored independently from the lyophilisate. Do not freeze.
What is the withdrawal period for Bovilis IBR Marker Live?
The withdrawal period from Bovilis IBR Marker Live is zero days.
What is the shelf life of Bovilis IBR Marker Live after opening?
Bovilis IBR Marker Live once reconstituted requires to be used in 3 hours.
Can Bovilis IBR Marker Live be administered and mixed with Bovilis BVD?
Safety and efficacy data are available which demonstrate that for the intramuscular revaccination – in cattle from 15 months of age onwards (i.e. those that have previously had separate primary courses of Bovilis IBR Marker Live and Bovilis BVD) - this vaccine can be mixed and administered with Bovilis BVD. The product literature of Bovilis BVD should be consulted before administration of the mixed products. The adverse effects observed after administration of one dose or an overdose of the mixed vaccines are not different from those described for the vaccines administered separately.
When mixed with Bovilis BVD at re-vaccination, the demonstrated efficacy claims for Bovilis IBR Marker Live are as follows:
- Active immunisation of cattle to reduce the fever induced by an infection with BHV-1
- Reduction of nasal excretion of field virus
Further information is available from the SPC, Datasheet or package leaflet.
Date of preparation: February 2022
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Bovilis® IBR Marker Live, Lyophilisate and Solvent for Suspension for Cattle, contains live Bovine Herpesvirus, POM-V
Bovilis® IBR marker inac Suspension for Injection for Cattle, contains inactivated Bovine Herpesvirus POM-V
Bovilis® BVD Suspension for Injection for Cattle, contains inactivated cytopathogenic Bovine Viral Diarrhoea (BVD) virus, POM-V
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